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pentobarbital will increase the level or impact of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers reduced ivosidenib plasma concentrations.pentobarbital will decrease the extent or result of ibuprofen by affecting hepatic enzyme CY

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